CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.

Kenya KobayashiYuki SaitoHidenori KageOsamu FukuokaKoji YamamuraToshiyuki MukaiKatsutoshi OdaTatsuya Yamasoba

Published in: Japanese journal of clinical oncology (2023)

CDK12 and ERBB2 co-amplification is associated with a poor prognosis in salivary duct carcinoma. Chromatin remodelling genes are deeply involved in tumour progression in adenoid cystic carcinoma. One such gene, ARID1A, was an independent prognostic factor. In salivary duct carcinoma and adenoid cystic carcinoma, there might be minor populations with mutations that could be targeted for treatment with the synthetic lethality approach.

Keyphrases

poor prognosis
long non coding rna
high grade
prognostic factors
genome wide
cell cycle
gene expression
transcription factor
emergency department
single cell
low grade
dna methylation
drug delivery
quality improvement
cancer therapy
replacement therapy
electronic health record