Lipolysis-stimulated lipoprotein receptor promote lipid uptake and fatty acid oxidation in gastric cancer.
Kota KawabataTsuyoshi TakahashiKoji TanakaYukinori KurokawaKazuyoshi YamamotoTakuro SaitoKota MomoseKotaro YamashitaTomoki MakinoTakashi YokouchiKunihiko KawaiSatoshi SeradaMinoru FujimotoKiyokazu NakajimaTetsuji NakaHidetoshi EguchiYuichiro DokiPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)
We demonstrated that lipids are taken up into gastric cancer cells via LSR and cause an increase in β-oxidation, resulting in the promotion of cancer progression. Controlling LSR-mediated lipid metabolism may be a novel therapeutic strategy for gastric cancer.