Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: central nervous system depression and pseudo-hallucinations.

NeuroCart tests indicated central nervous system (CNS) depressant effects. Oxathridine also unexpectedly caused pseudohallucinations. Although this led to the decision to stop further development of oxathridine, these observations suggest that the H3R system could be an interesting new target for the development of novel antipsychotics.