Jules A A C Heuberger

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 26

Top Venues

Clinical and translational science

British journal of clinical pharmacology

Clinical pharmacology and therapeutics

Movement disorders : official journal of the Movement Disorder Society

Centre for Human Drug Research

Leiden University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Centre for Human Drug Research Sep 01 2013

Netherlands

Senior Clinical Scientist

Education History

Leiden University Sep 01 2013 - May 16 2019

Netherlands

PHD :: Leiden University Medical Centre / Centre for Human Drug Research

Leiden University Sep 01 2007 - Jul 01 2013

Netherlands

MSC :: Bio-Pharmaceutical Sciences

Publications

Martin Skov, Titia Q Ruijs, Thomas S Grønnebæk, Marianne Skals, Anders Riisager, Jeppe Blichfeldt Winther, Kamilla Løhde Tordrup Dybdahl, Anders Findsen, Jeanette J Morgen, Nete Huus, Martin Broch-Lips, Ole B Nielsen, Catherine M K E de Cuba, Jules A A C Heuberger, Marieke L de Kam, Martijn R Tannemaat, Jan J G M Verschuuren, Lars J S Knutsen, Nicholas M Kelly, Klaus G Jensen, William David Arnold, Arthur H M Burghes, Claus Olesen, Jane Bold, Thomas K Petersen, Jorge A Quiroz, John Hutchison, Eva R Chin, Geert Jan Groeneveld, Thomas Holm Pedersen
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Science translational medicine 16 (739) (2024)
Andriy A Gorbenko, Jules A A C Heuberger, Linda E Klumpers, Marieke L de Kam, Pamela K Strugala, Saco J de Visser, Geert Jan Groeneveld
Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ 9 -Tetrahydrocannabinol Without Improving Its Analgesic Properties. Clinical pharmacology and therapeutics (2024)
Martin Skov, Titia Q Ruijs, Thomas S Grønnebæk, Marianne Skals, Anders Riisager, Jeppe Blichfeldt Winther, Kamilla Løhde Tordrup Dybdahl, Anders Findsen, Jeanette J Morgen, Nete Huus, Martin Broch-Lips, Ole B Nielsen, Catherine M K E de Cuba, Jules A A C Heuberger, Marieke L de Kam, Martijn R Tannemaat, Jan J G M Verschuuren, Lars J S Knutsen, Nicholas M Kelly, Klaus G Jensen, William David Arnold, Arthur H M Burghes, Claus Olesen, Jane Bold, Thomas K Petersen, Jorge A Quiroz, John Hutchison, Eva R Chin, Geert Jan Groeneveld, Thomas Holm Pedersen
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Science translational medicine 16 (739) (2024)
Martin Skov, Titia Q Ruijs, Thomas S Grønnebæk, Marianne Skals, Anders Riisager, Jeppe Blichfeldt Winther, Kamilla Løhde Tordrup Dybdahl, Anders Findsen, Jeanette J Morgen, Nete Huus, Martin Broch-Lips, Ole B Nielsen, Catherine M K E de Cuba, Jules A A C Heuberger, Marieke L de Kam, Martijn R Tannemaat, Jan J G M Verschuuren, Lars J S Knutsen, Nicholas M Kelly, Klaus G Jensen, William David Arnold, Arthur H M Burghes, Claus Olesen, Jane Bold, Thomas K Petersen, Jorge A Quiroz, John Hutchison, Eva R Chin, Geert Jan Groeneveld, Thomas Holm Pedersen
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Science translational medicine 16 (739) (2024)
Maurits F J M Vissers, Matthew D Troyer, Eva Thijssen, Jules A A C Heuberger, Geert Jan Groeneveld, Sarah Huntwork-Rodriguez
A Leucine-Rich Repeat Kinase 2 (LRRK2) Pathway Biomarker Characterization Study in Patients with Parkinson's Disease with and without LRRK2 Mutations and Healthy Controls. Clinical and translational science (2023)
Francis M Dijkstra, Rob G J A Zuiker, Jules A A C Heuberger, Kawita M S Kanhai, Marieke De Kam, Thierry Duvauchelle, Jeanne-Marie Lecomte, Olivier Labeeuw, Laurent Landais, Xavier Ligneau, Philippe Robert, Marc Capet, Jean-Charles Schwartz, Joop M A van Gerven
Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: central nervous system depression and pseudo-hallucinations. British journal of clinical pharmacology (2023)
Danna Jennings, Sarah Huntwork-Rodriguez, Maurits F J M Vissers, Vinay M Daryani, Dolores Diaz, Marisa S Goo, John J Chen, Romeo D Maciuca, Kyle Fraser, Omar S Mabrouk, Jeroen van de Wetering de Rooij, Jules A A C Heuberger, Geert Jan Groeneveld, Marie T Borin, Andrés Cruz-Herranz, Danielle Graham, Kimberly A Scearce-Levie, Javier De Vicente, Anastasia G Henry, Peter Chin, Carole Ho, Matthew D Troyer
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society (2023)
Danna Jennings, Sarah Huntwork-Rodriguez, Maurits F J M Vissers, Vinay M Daryani, Dolores Diaz, Marisa S Goo, John J Chen, Romeo D Maciuca, Kyle Fraser, Omar S Mabrouk, Jeroen van de Wetering de Rooij, Jules A A C Heuberger, Geert Jan Groeneveld, Marie T Borin, Andrés Cruz-Herranz, Danielle Graham, Kimberly A Scearce-Levie, Javier De Vicente, Anastasia G Henry, Peter Chin, Carole Ho, Matthew D Troyer
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society 38 (3) (2023)
Danna Jennings, Sarah Huntwork-Rodriguez, Maurits F J M Vissers, Vinay M Daryani, Dolores Diaz, Marisa S Goo, John J Chen, Romeo D Maciuca, Kyle Fraser, Omar S Mabrouk, Jeroen van de Wetering de Rooij, Jules A A C Heuberger, Geert Jan Groeneveld, Marie T Borin, Andrés Cruz-Herranz, Danielle Graham, Kimberly A Scearce-Levie, Javier De Vicente, Anastasia G Henry, Peter Chin, Carole Ho, Matthew D Troyer
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society 38 (3) (2023)
Maurits F J M Vissers, Matthew D Troyer, Eva Thijssen, Jules A A C Heuberger, Geert Jan Groeneveld, Sarah Huntwork-Rodriguez
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls. Clinical and translational science (2023)
Titia Q Ruijs, Ingrid W Koopmans, Marieke L de Kam, Michiel J van Esdonk, Martin Koltzenburg, Geert Jan Groeneveld, Jules A A C Heuberger
Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Clinical pharmacology and therapeutics 112 (5) (2022)
Maurits F J M Vissers, Jules A A C Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M Tsai, Andres Cruz-Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce-Levie, Jennifer Hsiao-Nakamoto, Xinyan Tang, Megan Chang, Brian M Fox, Anthony A Estrada, Robert J Pomponio, Miguel Alonso-Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D Troyer, Carole Ho
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients. Clinical and translational science 15 (8) (2022)
Titia Q Ruijs, Jules A A C Heuberger, Annika A de Goede, Dimitrios Ziagkos, Marije E Otto, Robert-Jan Doll, Michel J A M van Putten, Geert Jan Groeneveld
Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double-blind, placebo-controlled, cross-over study. British journal of clinical pharmacology 88 (6) (2022)
Boudewijn T H M Sleutjes, Diederik J L Stikvoort García, Maria O Kovalchuk, Jules A A C Heuberger, Geert Jan Groeneveld, Hessel Franssen, Leonard H van den Berg
Acute retigabine-induced effects on myelinated motor axons in amyotrophic lateral sclerosis. Pharmacology research & perspectives 10 (4) (2022)
Titia Q Ruijs, Ingrid W Koopmans, Marieke L de Kam, Martijn R Tannemaat, Geert Jan Groeneveld, Jules A A C Heuberger
Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double-blind placebo-controlled cross-over study. Clinical and translational science (2022)
Laurence M Moss, Marijke Hyke Algera, Robert Dobbins, Frank Gray, Stephanie Strafford, Amy Heath, Monique van Velzen, Jules A A C Heuberger, Marieke Niesters, Erik Olofsen, Celine M Laffont, Albert Dahan, Geert Jan Groeneveld
Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients. PloS one 17 (1) (2022)
Patricio O'Donnell, Francis M Dijkstra, Ugur Damar, Lei Quanhong, Annika A de Goede, Lin Xu, Andres Pascual-Leone, Derek L Buhl, Rob G J A Zuiker, Titia Q Ruijs, Jules A A C Heuberger, Paul MacMullin, Martin Lubell, Mahnaz Asgharnejad, Venkatesha Murthy, Alexander Rotenberg, Gabriel E Jacobs, Laura Rosen
Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation. Translational psychiatry 11 (1) (2021)
Maurits F J M Vissers, Jules A A C Heuberger, Geert Jan Groeneveld
Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders. International journal of molecular sciences 22 (4) (2021)
Daniel Hidalgo, Bejder Jacob, Ramona Pop, Kyle J Gellatly, Yung Hwang, S Maxwell Scalf, Anna E Eastman, Jane-Jane Chen, Julie Lihua Zhu, Jules A A C Heuberger, Shangqin Guo, Mark J Koury, Nikolai Baastrup Nordsborg, Merav Socolovsky
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature communications 12 (1) (2021)
Jules A A C Heuberger, April Henning, Adam A Cohen, Bengt Kayser
Dealing with doping. A plea for better science, governance and education. British journal of clinical pharmacology (2021)
Jules A A C Heuberger, Adam F Cohen
Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects. Sports medicine (Auckland, N.Z.) 49 (4) (2020)
Jules A A C Heuberger, Jelle J Posthuma, Dimitrios Ziagkos, Joris I Rotmans, Johannes M A Daniels, Pim Gal, Frederik E Stuurman, Henri M H Spronk, Hugo Ten Cate, Jacobus Burggraaf, Matthijs Moerland, Adam F Cohen
Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes. European journal of applied physiology 120 (8) (2020)
Jules A A C Heuberger, Peter van Eenoo, Joris I Rotmans, Pim Gal, Frederik E Stuurman, Titiaan E Post, Johannes M A Daniels, Herman Ram, Olivier de Hon, Jacobus Burggraaf, Adam F Cohen
Sensitivity and specificity of detection methods for erythropoietin doping in cyclists. Drug testing and analysis 11 (9) (2019)
Hendrika W Grievink, Jules A A C Heuberger, Fen Huang, Rinkal Chaudhary, Willem A J Birkhoff, George R Tonn, Sofia Mosesova, Rebecca Erickson, Matthijs Moerland, Patrick C G Haddick, Kimberly Scearce-Levie, Carole Ho, Geert Jan Groeneveld
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. Clinical pharmacology and therapeutics 107 (2) (2019)
Jules A A C Heuberger, Sven C van Dijkman, Adam A Cohen
Futility of current urine salbutamol doping control. British journal of clinical pharmacology 84 (8) (2018)
Jules A A C Heuberger, Pim Gal, Frederik E Stuurman, Wouter A S de Muinck Keizer, Yuri Mejia Miranda, Adam F Cohen
Repeatability and predictive value of lactate threshold concepts in endurance sports. PloS one 13 (11) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jules A A C Heuberger