Association of genetically predicted lipid traits and lipid-modifying targets with heart failure.

Jun XiaoJianguang JiNaiqi ZhangXi YangKeyuan ChenLiangwan ChenWuqing Huang

Published in: European journal of preventive cardiology (2023)

This two-sample MR study provided genetic evidence of the associations between lipid traits and HF risk, which were mostly mediated by CHD. Besides, drug target MR studies indicated that PCSK9 inhibition, CETP inhibition, and LPL activation were effective in HF reduction.

Keyphrases

heart failure
genome wide
fatty acid
acute heart failure
contrast enhanced
emergency department
dna methylation
gene expression
computed tomography
copy number