Pain hypersensitivity, sensorimotor impairment, and decreased muscle force in a novel rat model of radiation-induced peripheral neuropathy.

Allison B VittertMelissa DanielShelby R SvientekMary Jane RischNoah S NelsonAlexis DonneysAmir DehdashtianGina N SacksSteven R BuchmanStephen William Peter Kemp

Published in: Journal of the peripheral nervous system : JPNS (2024)

A clinically relevant human equivalent dose of fractionated 35 Gy in rats established significant pain hypersensitivity, impairments in sensorimotor locomotion, and decreased muscle force capacity. This novel rodent model of radiation-induced peripheral neuropathy can be utilized to assess the potential efficacy of therapeutic treatments to either prevent or remediate this clinically debilitating condition.

Keyphrases

radiation induced
chronic pain
radiation therapy
pain management
skeletal muscle
neuropathic pain
single molecule
endothelial cells
functional connectivity
drug induced
spinal cord
spinal cord injury
small cell lung cancer
pluripotent stem cells
risk assessment
human health