Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro.
Sergey BrezginAnastasiia KostyushevaEkaterina O BayurovaIlya V GordeychukMaria IsaguliantsIrina GoptarAnastasiia NikiforovaValery SmirnovElena VolchkovaDieter GlebeDmitry KostyushevVladimir P ChulanovPublished in: Microorganisms (2019)
Formation and maintenance of HBV cccDNA pools may be partially suppressed by the baseline expression of host inhibitory factors including APOBEC3A and APOBEC3B. HBV inflicts DNA damage both directly and by inducing DNMT3A expression.