Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.
Sander BeelSarah HerdewynRaheem FazalMathias De DeckerMatthieu MoisseWim RobberechtLudo Van Den BoschPhilip Van DammePublished in: Molecular neurodegeneration (2018)
Our findings reveal an important role of PGRN in attenuating mutant TDP-43-induced neurodegeneration.