Effects of Tumor Necrosis Factor Alpha on the Expression of Programmed Cell Death Factor 5 in Arthritis.

Ke-Shi ZhangJun-Feng WangShao-Long ZhangZhao LiZheng PeiZhen-Peng Guan

Published in: Orthopaedic surgery (2019)

The expression of PDCD5 as well as TNF-α in osteoarthritis cartilage and synovium was significantly higher than in healthy tissues, and TNF-α can promote the proliferation of FLS cells in patients with rheumatoid arthritis, and inhibit the expression of PDCD5. PDCD5 may be involved in the abnormal proliferation of synoviocytes and the degeneration of chondrocytes stimulated by TNF-α.

Keyphrases

rheumatoid arthritis
poor prognosis
signaling pathway
binding protein
induced apoptosis
gene expression
cell death
knee osteoarthritis