Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.
Alexandra Coomans de BrachèneMaria Ines AlvelosFlorian SzymczakPriscila L ZimathAngela CastelaBianca Marmontel de SouzaArturo Roca RivadaSandra Marín-CañasXiaoyan YiAnne Op de BeeckNoel G MorganSebastian SonntagSayro JawurekAlexandra C TitleBurcak YesildagFrançois PattouJulie Kerr-ConteEduard MontanyaMontserrat NacherLorella MarselliPiero MarchettiSarah J RichardsonDecio L EizirikPublished in: Diabetologia (2024)
These data suggest that IFN-α and IFN-γ are key cytokines at the islet level in human type 1 diabetes, contributing to the triggering and amplification of autoimmunity.