An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression.

Hari Prasad Susmita Mandal John Kandam Kulathu Mathew Aparna Cherukunnath Atchuta Srinivas Duddu Mallar Banerjee Harini Ramani Ramray Bhat Mohit Kumar Jolly Sandhya Srikant Visweswariah

Published in: Molecular cancer research : MCR (2024)

Endosomal pH regulator NHE9 actively controls cytosolic Ca2+ levels to downregulate the adenylate cyclase-cAMP system, enabling colorectal cancer cells to acquire hybrid E/M characteristics and promoting metastatic progression.

Keyphrases

protein kinase
transcription factor
binding protein
squamous cell carcinoma
poor prognosis
small cell lung cancer