REVEALS-a longitudinal cohort study of multifaceted respiratory assessment in ALS.

James P K Rooney Deirdre Murray Dara Meldrum Ammar Al ChalabiTommy BunteTheresa ChiweraMutahhara ChoudhuryAdriano ChioLauren FentonJennifer FortuneLindsay MaidmentUmberto Manera Christopher J McDermottMyrte MeyjesRachel TattersallMaria Claudia Torrieri Philip Van DammeElien VanderlindenClaire WoodLeonard H van den Berg Orla Hardiman

Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2024)

Respiratory function declines more quickly in females with ALS compared with males when measured by FVC, SVC, SNIP, or PCF, but not the ALSFRS-R respiratory sub-score. Higher baseline King's staging and the presence of clinical respiratory symptoms at baseline were associated with worse respiratory function. The ALSFRS-R respiratory sub-score is poorly correlated with objective respiratory measurements.

Keyphrases

respiratory tract