Pathogenesis of pelvic pain syndrome associated with endometriosis in patients resistant to surgical treatment.
Victor RadzinskyMekan OrazovOlga SharapovaMarina KhamoshinaPublished in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2021)
The results of the study have shown that the basis of pathogenesis of pelvic pain recurrence in patients who did not receive medical therapy after surgical treatment of EGE is the activation of neuro-angiogenesis processes and reduction of apoptosis. The results show a statistically significant 1.6 times increasing expression of NGF in eutopic endometrium (57.9 ± 2.5 vs 35.3 ± 2.1% of patients with the silent form of the gene and its receptor NTRK1 1.8 times (2.78 ± 0.25 versus 1.56 ± 0.21.e. respectively). Conclusion: The pathogenesis of pelvic pain in patients who did not receive medical therapy after surgical treatment of endometriosis compared to no pain form of the disease is the activation of the processes of neurogenesis in the eutopic endometrium.
Keyphrases
- chronic pain
- pain management
- neuropathic pain
- end stage renal disease
- rectal cancer
- healthcare
- chronic kidney disease
- newly diagnosed
- ejection fraction
- endothelial cells
- poor prognosis
- oxidative stress
- cell death
- peritoneal dialysis
- endoplasmic reticulum stress
- vascular endothelial growth factor
- growth factor
- cell cycle arrest
- bone marrow