Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP-43 pathology.
Barış GençMukesh GautamÖge GözütokIna DervishiSantana SanchezGashaw M GoshuNuran KoçakEdward XieRichard B SilvermanP Hande ÖzdinlerPublished in: Clinical and translational medicine (2021)
Mechanism-focused and cell-based drug discovery approaches not only addressed key cellular defects responsible for UMN loss, but also identified NU-9, the first compound to improve the health of diseased UMNs, neurons that degenerate in ALS, HSP, PLS, and ALS/FTLD patients.
Keyphrases
- drug discovery
- amyotrophic lateral sclerosis
- healthcare
- end stage renal disease
- ejection fraction
- newly diagnosed
- public health
- single cell
- oxidative stress
- prognostic factors
- mental health
- spinal cord
- cell therapy
- heat shock protein
- heat stress
- patient reported outcomes
- health information
- risk assessment
- social media
- breast cancer cells
- bone marrow
- health promotion
- mesenchymal stem cells
- climate change