GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma.

Sawako SuzukiDivya VenkateshHiroaki KandaAkitoshi NakayamaHiroyuki HosokawaEunyoung LeeTakashi Miki Brent R Stockwell Koutaro Yokote Tomoaki Tanaka Carol Prives

Published in: Cancer research (2022)

This study demonstrates that the key regulator of glutaminolysis, GLS2, can limit HCC in vivo by promoting ferroptosis through αKG-dependent lipid ROS, which in turn might lay the foundation for a novel therapeutic approach.

Keyphrases

cell death
transcription factor
dna damage
reactive oxygen species
single molecule