P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site.

Jonathan D MarottiKristen E MullerLaura J TafeEugene DemidenkoTodd W Miller

Published in: International journal of breast cancer (2017)

P-Rex1 expression is increased in ER+ and HER2+ breast cancers compared to triple-negative tumors. P-Rex1 may be differentially expressed in metastatic tumors based on site and receptor status. The role of P-Rex1 in the development of breast cancer metastases and as a predictive biomarker of therapeutic response warrants further investigation.

Keyphrases

poor prognosis
squamous cell carcinoma
binding protein
small cell lung cancer
lymph node
young adults
endoplasmic reticulum
breast cancer risk