Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study.
Nicole VogelzangsCarla J H van der KallenMarleen M J van GreevenbroekBirgitta W van der KolkJohan W E JockenGijs H GoossensNicolaas C SchaperRonald M A HenrySimone J P M EussenArmand ValsesiaThomas HankemeierArnie AstrupWim H M SarisCoen D A StehouwerEllen E BlaakIlja C W Artsnull nullPublished in: International journal of obesity (2005) (2020)
In persons with obesity without diabetes, both liver and muscle IR show a circulating metabolic profile of elevated (branched-chain) amino acids, lactate, and triglycerides, and lower glycine levels, but only liver IR associates with lower ketone body levels and elevated ketogenic amino acids in circulation, suggestive of decreased ketogenesis. This knowledge might enhance developments of more targeted tissue-specific interventions to prevent progression to more severe disease stages.