Size matters: the impact of nucleus size on results from spatial transcriptomics.

Elyas MohammadiKatarzyna ChojnowskaMichał BieńkowskiAnna KosteckaMagdalena KoczkowskaMichał A ŻmijewskiMarcin JąkalskiMartin IngelssonNatalia FilipowiczPaweł OlszewskiHanna DaviesJustyna M WierzbickaBradley T HymanJan P DumanskiArkadiusz PiotrowskiJakub Mieczkowski

Published in: Journal of translational medicine (2023)

CSDI can be applied to investigate consecutive sections studied with ST in the human cerebral cortex, avoiding misinterpretation of spot clustering and annotation, increasing accuracy of cell recognition as well as improvement in uncovering the layers of grey matter in the human brain.

Keyphrases

single cell
rna seq
endothelial cells
subarachnoid hemorrhage
functional connectivity
white matter
induced pluripotent stem cells
pluripotent stem cells
stem cells
bone marrow
cerebral ischemia
brain injury