Immune marker spatial distribution and clinical outcome after PD-1 blockade in mismatch repair-deficient, advanced colorectal carcinomas.
Bahar Saberzadeh-ArdestaniRondell P GrahamSara McMahonEze AhanonuQian ShiCrystal WilliamsAntony HubbardWenjun ZhangAndrea MuranyiDongyao YanZhaohui JinKandavel ShanmugamFrank A SinicropePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
In d-MMR CRCs, PD-1+ to PD-L1+ receptor to ligand proximity is a potential predictive biomarker for the effectiveness of PD-1 blockade.