Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells.
Srikanth BarkeerSeema ChughSaswati KarmakarGarima KaushikSanchita RauthSatyanarayana RachaganiSurinder K BatraMoorthy Palanimuthu PonnusamyPublished in: BMC cancer (2018)
Taken together, for the first time, our study showed the importance of glycosylation in mediating growth, stemness, and maintenance of PCSCs. These results indicate that elevated GALNT3 and B3GNT3 expression in PCSCs regulate stemness through modulating CSC markers.