Three-dimensional quantitative MRI of aerosolized gadolinium-based nanoparticles and contrast agents in isolated ventilated porcine lungs.
Yannick CrémillieuxYoann MontigaudClémence BalNoël PinaudVi PhamSophie PerinelMarco NatuzziFrançois LuxOlivier TillementNobuyasu IchinoseBei ZhangJérémie PourchezPublished in: Magnetic resonance in medicine (2019)
The distribution of aerosolized gadolinium-based contrast agent or nanoparticles can be visualized and quantified using UTE MRI in large animal ventilated lung model on a clinical MRI scanner. This protocol can be used for assessing and quantifying aerosol regional deposition with high spatial resolution (1 mm 3D isotropic) without ionizing radiation and could be applied in the future for diagnostic or therapeutic applications in patients.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- magnetic resonance
- computed tomography
- diffusion weighted imaging
- intensive care unit
- end stage renal disease
- acute respiratory distress syndrome
- ejection fraction
- newly diagnosed
- randomized controlled trial
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- high resolution
- single molecule
- current status
- mass spectrometry
- water soluble