Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts.
Elizabeth Ann L EnningaHuy Quang QuachJin Sung JangMaria Cristina Miranda de Araujo CorreiaYaroslav FedyshynBohdana FedyshynMaureen LemensDawn LittlefieldSupriya BehlElise Sintim-AboagyeMaria C Mejia PlazasMaria C CardenasShree ChakrabortySatoko YamaokaHideki EbiharaAkhilesh PandeyHu LiAndrew D BadleyErica L JohnsonJie SunAndrew P NorganRegan N TheilerHuy Quang QuachPublished in: PLoS pathogens (2024)
Our studies demonstrate a significant impact of indirect SARS-CoV-2 infection on gene expression of inner mesenchymal HBCs, with limited effect on lining CTB cells isolated from pregnant subjects infected and recovered from SARS-CoV-2. The pathways associated with these DEGs identify potential targets for therapeutic intervention.
Keyphrases
- gene expression
- induced apoptosis
- sars cov
- cell cycle arrest
- dna methylation
- respiratory syndrome coronavirus
- randomized controlled trial
- stem cells
- endoplasmic reticulum stress
- pregnant women
- bone marrow
- oxidative stress
- cell death
- preterm birth
- risk assessment
- coronavirus disease
- birth weight
- climate change
- pi k akt