Sustainable Gold Nanoparticle (Au-NP) Growth within Interspaces of Porphyrinic Zirconium-Based Metal-Organic Frameworks: Green Synthesis of PCN-224/Au-NPs and Its Anticancer Effect on Colorectal Cancer Cells Assay.
Sajedeh Tehrani NejadRahmatollah RahimiMina NajafiSadegh RostamniaPublished in: ACS applied materials & interfaces (2024)
In this work, a simple green synthesis method of the novel metal-organic framework (MOF) nanocomposite PCN-224/Au-NPs (Au-NPs = gold nanoparticles) is described. In this regard, initially, PCN-224 was synthesized. Afterward, in a single-step, one-pot procedure, under visible-light irradiation, Au-NPs were fabricated on PCN-224. The cytotoxicity effect of the synthesized PCN-224/Au-NPs nanocomposite was investigated in human colon cancer cells. Determination of the apoptosis induction was done by the Annexin- V/propidium iodide flow cytometry method. Besides, to ascertain the biocompatibility of the synthesized sample, the cytotoxicity of PCN-224/Au-NPs was evaluated on the human embryonic kidney (HEK)-293 cell line. The substantial anticancer activity with the biocompatibility of the structure, the green facile synthesis, and the MOF surface of the synthesized nanocomposite make it special for utilization in therapeutic applications.
Keyphrases
- metal organic framework
- reduced graphene oxide
- visible light
- gold nanoparticles
- oxide nanoparticles
- sensitive detection
- flow cytometry
- endothelial cells
- quantum dots
- oxidative stress
- high throughput
- solid phase extraction
- cell death
- radiation therapy
- mass spectrometry
- single molecule
- cell cycle arrest
- pluripotent stem cells
- pi k akt
- atomic force microscopy