Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms.

Friederike Irmen Christos Ganos Philip E Mosley Alistair Perry Jan Niklas Petry-SchmelzerHaidar S DafsariMichael BarbeVeerle Visser-VandewalleGerd-Helge SchneiderNingfei LiDorothee KüblerGregor WenzelAndrea A Kühn

Published in: Annals of neurology (2020)

Fibers connecting the electrode with left prefrontal areas were associated with worsening of depressive symptoms. Our results suggest that for the left STN-DBS lead, placement impacting fibers to left prefrontal areas should be avoided to maximize improvement of depressive symptoms. ANN NEUROL 2020;87:962-975.

Keyphrases

depressive symptoms
functional connectivity
working memory
social support
deep brain stimulation
resting state
transcranial magnetic stimulation
sleep quality
parkinson disease
physical activity