Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms.
Friederike IrmenChristos GanosPhilip E MosleyAlistair PerryJan Niklas Petry-SchmelzerHaidar S DafsariMichael BarbeVeerle Visser-VandewalleGerd-Helge SchneiderNingfei LiDorothee KüblerGregor WenzelAndrea A KühnPublished in: Annals of neurology (2020)
Fibers connecting the electrode with left prefrontal areas were associated with worsening of depressive symptoms. Our results suggest that for the left STN-DBS lead, placement impacting fibers to left prefrontal areas should be avoided to maximize improvement of depressive symptoms. ANN NEUROL 2020;87:962-975.