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Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms.

Friederike IrmenChristos GanosPhilip E MosleyAlistair PerryJan Niklas Petry-SchmelzerHaidar S DafsariMichael BarbeVeerle Visser-VandewalleGerd-Helge SchneiderNingfei LiDorothee KüblerGregor WenzelAndrea A Kühn
Published in: Annals of neurology (2020)
Fibers connecting the electrode with left prefrontal areas were associated with worsening of depressive symptoms. Our results suggest that for the left STN-DBS lead, placement impacting fibers to left prefrontal areas should be avoided to maximize improvement of depressive symptoms. ANN NEUROL 2020;87:962-975.
Keyphrases
  • depressive symptoms
  • functional connectivity
  • working memory
  • social support
  • deep brain stimulation
  • resting state
  • transcranial magnetic stimulation
  • sleep quality
  • parkinson disease
  • physical activity