Digoxin treatment does not reinduce radioiodine uptake in radioiodine refractory non-medullary thyroid carcinoma.

Pepijn van HoutenJames NagarajahJanneke E W WalravenMartin JaegerAdriana C H van Engen-van GrunsvenJohannes W SmitRomana T Netea-Maier

Published in: European thyroid journal (2024)

Contrary to results from preclinical trials, in this trial, 3 weeks of digoxin treatment did not reinduce RAI uptake in patients with NMTC. This highlights essential challenges regarding the approach toward optimization of studies aimed to restore the RAI uptake and its therapeutic efficacy through drug repurposing.

Keyphrases

clinical trial
randomized controlled trial
stem cells
study protocol
cell therapy
phase ii
bone marrow
drug induced
preterm birth
open label
drug discovery
gestational age
double blind