The Menin story in acute myeloid leukaemia-The road to success.
Michael W M KühnArnold GanserPublished in: British journal of haematology (2024)
The treatment of acute myeloid leukaemia (AML) has changed fundamentally in the last decade with many new targeted therapies entering clinics. Some of the most interesting agents under development are Menin inhibitors which interfere with the interaction of Menin with wild-type (wt) KMT2A or a KMT2A-fusion protein and thereby downregulate the leukaemic gene expression (MEIS1, PBX3, HOX) in NPM1 mutant or KMT2A-rearranged leukaemia. Other HOX and MEIS1 expressing leukaemias may also be sensitive to Menin inhibition. Following the encouraging results as monotherapy in refractory and relapsed AML, the combination of Menin inhibitors with chemotherapeutic agents and other targeted drugs is being investigated clinically.
Keyphrases
- acute myeloid leukemia
- wild type
- gene expression
- liver failure
- allogeneic hematopoietic stem cell transplantation
- respiratory failure
- drug induced
- dendritic cells
- dna methylation
- bone marrow
- primary care
- combination therapy
- aortic dissection
- cancer therapy
- hepatitis b virus
- multiple myeloma
- randomized controlled trial
- open label
- immune response
- intensive care unit
- clinical trial
- drug delivery
- atomic force microscopy