Assessment of Immunological Effects of Low-Level Er: YAG Laser Radiation.
Mojtaba AnsariMostafa Rezaei TaviraniMaryam Hamzeloo-MoghadamReza VafaeeMohhamadreza RazzaghiMahfam NikzamirMohammad Rostami-NejadMona Zamanizn AzodiPublished in: Journal of lasers in medical sciences (2022)
Introduction: Low-level laser radiation has a significant effect on cell proliferation. Various investigations into the effect of Er: YAG laser on the treated cell lines have been published. Determining core targeted proteins is an attractive subject. This research aimed at identifying the critical targeted protein by a low-level Er: YAG laser in primary osteoblast-like cells. Methods: Data were extracted from the literature about proteomic assessment of 3.3 J/cm 2 of low-level Er: YAG laser radiation on osteoblast-like cells of rat calvaria. The significant differentially expressed proteins plus 100 first neighbors were analyzed via network analysis and gene ontology enrichment. Results: Nine differentially expressed proteins among the 12 queried proteins were included in the main connected component. Analysis revealed that Cxcl1 was a key targeted protein in response to laser radiation. The presence of Cxcl1 in the significant cellular pathways indicated that cell growth and proliferation were affected. Conclusion: It can be concluded that the immune system is affected by the laser to activate cellular defense against stress.
Keyphrases
- high speed
- cell proliferation
- estrogen receptor
- cancer therapy
- oxidative stress
- gene expression
- signaling pathway
- randomized controlled trial
- breast cancer cells
- genome wide
- machine learning
- radiation therapy
- copy number
- single cell
- heat stress
- amino acid
- protein protein
- newly diagnosed
- artificial intelligence
- big data
- label free