Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression.
Walison Nunes da SilvaPedro Augusto Carvalho CostaSérgio Ricardo Aluotto Scalzo JúniorHeloísa Athaydes Seabra FerreiraPedro Henrique Dias Moura PrazeresCaroline Leonel Vasconcelos CamposMarco Túllio Rodrigues AlvesNatália Jordana Alves da SilvaAna Luiza de Castro SantosLays Cordeiro GuimarãesMaria Eduarda Chen FerrisAjay ThatteAlex HamiltonKelly Alves BicalhoAnderson Oliveira LoboHelton da Costa SantiagoLucíola da Silva BarcelosMaria Marta FigueiredoMauro Martins TeixeiraVivian Vasconcelos CostaMichael J MitchellFrédéric FrézardPedro Pires Goulart GuimaraesPublished in: International journal of nanomedicine (2024)
Together, our data demonstrate the potential of the LNP to deliver TRAIL mRNA to the TME and to induce tumor cell death, especially when combined with TME normalization. Therefore, these findings provide important insights for the development of novel therapeutic strategies for the immunotherapy of solid tumors.