Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.

Jun-Ichi KashiwakuraKodai SaitohTakeru IharaYuto SasakiKota KagohashiShiyo EnoharaYuka MoriokaHiroshi WataraiRyuta MuromotoYuichi KitaiKazuya IwabuchiKenji OritaniTadashi Matsuda

Published in: PloS one (2020)

These results conclude that STAP-1 regulates iNKT cell maintenance/activation, and is involved in the pathogenesis of autoimmune hepatitis.

Keyphrases

multiple sclerosis
poor prognosis
single cell
binding protein
cell therapy
mesenchymal stem cells
bone marrow
small molecule