The Role of Lactobacillus plantarum in Reducing Obesity and Inflammation: A Meta-Analysis.
Chen-Pi LiChin-Chang ChenYao HsiaoChieh-Hsin KaoChin-Chu ChenHao-Jan YangRu-Yin TsaiPublished in: International journal of molecular sciences (2024)
Recent research has underscored the efficacy of Lactobacillus plantarum (L. plantarum) in managing obesity among healthy adults. This meta-analysis reviewed randomized controlled trials (RCTs) from major databases up to May 2024, focusing on the effects of L. plantarum on body weight, body mass index (BMI), and metabolic parameters. This study has been registered in PROSPERO (number: CRD 42024531611). The analysis of nine studies revealed significant weight reduction and BMI decreases with L. plantarum supplementation compared to a placebo. Notably, using more than two strains together enhanced these effects. Improvements were also observed in abdominal fat and inflammatory markers such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP). This meta-analysis synthesizes evidence from nine RCTs to test the hypothesis that L. plantarum supplementation effectively reduces body weight and BMI in healthy adults compared to a placebo. However, variations in study designs, probiotic strains, and intervention durations call for more robust trials to confirm these benefits.
Keyphrases
- body weight
- body mass index
- weight gain
- systematic review
- randomized controlled trial
- weight loss
- meta analyses
- metabolic syndrome
- insulin resistance
- escherichia coli
- type diabetes
- oxidative stress
- physical activity
- adipose tissue
- clinical trial
- skeletal muscle
- machine learning
- study protocol
- deep learning
- artificial intelligence
- phase iii