Upregulation of miR-146a-5p is associated with increased proliferation and migration of vascular smooth muscle cells in aortic dissection.

Ling XueSongyuan LuoHuanyu DingYuan LiuWenhui HuangXiaoping FanMin WuXuhua JianCheng HuangJianFang LuoRuixin Fan

Published in: Journal of clinical laboratory analysis (2019)

The expression of SMAD4 was modulated by miR-146a-5p. miR-146a-5p induced VSMC proliferation and migration through targeting SMAD4 and hence might be potentially involved in the development of AD.

Keyphrases

vascular smooth muscle cells
aortic dissection
poor prognosis
transforming growth factor
epithelial mesenchymal transition
angiotensin ii
high glucose
diabetic rats
long non coding rna
cell proliferation
signaling pathway
cancer therapy
drug induced
oxidative stress