Association between psychological vulnerability and glaucoma progression: Protocol for a multicenter prospective cohort study in South Korea.
Sung Uk BaekJin-Soo KimDai Woo KimAhnul HaYoung Kook KimPublished in: PloS one (2023)
This study is to be a prospective multicenter study conducted at four tertiary medical centers. Patients recently diagnosed with glaucoma and not yet treated will be enrolled. Anxiety, depression, and stress scales will be administered at baseline, one year, and two years, along with glaucomatous assessments to be performed every six months. Validated questionnaires (Generalized Anxiety Disorder Assessment [GAD-7], Patient Health Questionnaire [PHQ-9], and Perceived Stress Scale-10 [PSS-10]) will assess anxiety, depression, and stress, respectively. The primary objective is to correlate post-diagnosis psychological status with medication adherence and disease progression. The effects of pre- and post-diagnosis changes in anxiety, depression, and stress on disease progression will be analyzed. Kaplan-Meier survival analysis and logistic regression will be performed to identify clinical characteristics associated with increased risk of developing anxiety, depression, and stress in glaucoma patients.
Keyphrases
- sleep quality
- depressive symptoms
- end stage renal disease
- newly diagnosed
- healthcare
- ejection fraction
- chronic kidney disease
- stress induced
- peritoneal dialysis
- mental health
- prognostic factors
- physical activity
- optic nerve
- climate change
- clinical trial
- social support
- heat stress
- case report
- social media
- data analysis
- psychometric properties