Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Chuan ZhangDan DangLele CongHongyan SunXianling CongPublished in: Cancer medicine (2021)
Elevated IL2RA, IL2RG, IL7R, and IFNG expression may play a central role in promoting melanoma metastasis through up regulation of intratumoral regulatory T-cell proportion mainly by activation of JAK-STAT signaling pathway. LINC02446, LINC01857, and LINC02384 may stimulate melanoma progression by reducing tumor-protecting miR.891a.5p and miR.203b.3p. A number of identified molecules including TNFRSF13B, LAG3, NRP1, ENTPD1, NT5E, CCL21, and CCR7 can serve as future therapeutic targets in melanoma treatment.
Keyphrases
- long non coding rna
- cell proliferation
- long noncoding rna
- signaling pathway
- poor prognosis
- skin cancer
- basal cell carcinoma
- transcription factor
- pi k akt
- dendritic cells
- epithelial mesenchymal transition
- systemic lupus erythematosus
- binding protein
- regulatory t cells
- oxidative stress
- liver fibrosis
- disease activity
- drug induced