Profiling Fibroblast Growth Factor Receptor 3 Expression Based on the Immune Microenvironment in Upper Tract Urothelial Carcinoma.

Keisuke ShigetaKazuhiro MatsumotoSotaro KitaokaMinami OmuraKota UmedaYuki AritaShuji MikamiKeishiro FukumotoYota YasumizuNobuyuki TanakaToshikazu TakedaShinya MoritaTakeo KosakaRyuichi MizunoSatoshi HaraMototsugu Oya

Published in: European urology oncology (2024)

We conducted immunohistochemical staining to evaluate fibroblast growth factor receptor 3 (FGFR3)-related immune microenvironment by evaluating the expressions of CD4, CD8, CD68, CD163, CD204, and PD-L1 in 214 upper tract urothelial carcinoma patients. We identified three distinct immune clusters based on FGFR3 expressions and found that patients with a low FGFR3 expression but immune hot status received the maximum benefit from an immune checkpoint inhibitor.

Keyphrases

end stage renal disease
stem cells
newly diagnosed
poor prognosis
chronic kidney disease
peritoneal dialysis
single cell
patient reported outcomes