Medicine utilization studies in Australian individual-level dispensing data: A blinded, multi-center replicated analysis.

Malcolm Bjørn GilliesChrianna BharatXimena CamachoBenjamin DanielsKelly A Hall Thu-Lan Kelly Erin A KeltyJialing LinMelisa LitchfieldDerrick LopezFirouzeh NoghrehchiJacques RaubenheimerBianca VarneyNicole L Pratt

Published in: Pharmacoepidemiology and drug safety (2024)

Differences in analytical decisions when deriving exposure from dispensing data affect replicability. Detailed analytical protocols, such as HARPER, are critical for transparency of operational definitions and interpretations of key study parameters.

Keyphrases

electronic health record
big data
liquid chromatography
randomized controlled trial
clinical trial
data analysis
study protocol
mass spectrometry
deep learning