Using fractional exhaled nitric oxide to guide step-down treatment decisions in patients with asthma: a systematic review and individual patient data meta-analysis.

Kay WangJan Y VerbakelJason OkeAlexander Fleming-NouriJosh BrewinNia RobertsNorihiro HaradaRyo AtsutaKazuhisa TakahashiKazutaka MoriTomoyuki FujisawaToshihiro ShiraiTomotaka KawayamaHiromasa InoueStephen LazarusStanley SzeflerFernando MartinezDominick E ShawIan D PavordMichael Thomas

Published in: The European respiratory journal (2020)

In patients with mild-to-moderate asthma, gradual ICS reduction when F ENO is <50 ppb may help decrease ICS use without increasing exacerbations. Future research should aim to validate these findings in larger populations.

Keyphrases

chronic obstructive pulmonary disease
nitric oxide
systematic review
lung function
cystic fibrosis
allergic rhinitis
case report
meta analyses
electronic health record
hydrogen peroxide
randomized controlled trial
current status
big data
air pollution
machine learning
artificial intelligence
genetic diversity