Silibinin alleviates inflammation-induced bone loss by modulating biological interaction between human gingival fibroblasts and monocytes.

Ren-Yeong HuangHua-Yang ChangShu-Mi ChihThomas Van DykeChia-Dan ChengCheng-En SungPei-Wei WengYi-Shing ShiehWan-Chien Cheng

Published in: Journal of periodontology (2023)

Silibinin effectively inhibits inflammation-induced bone loss in experimental periodontitis based on the regulation of stimulated HGFs by inhibiting the expression of inflammatory and osteoclastogenic mediators.

Keyphrases

bone loss
oxidative stress
diabetic rats
high glucose
endothelial cells
signaling pathway
poor prognosis
drug induced
dendritic cells
long non coding rna
mouse model
binding protein
induced pluripotent stem cells