Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.
Mareike LehmannLara BuhlHani N AlsafadiStephan KleeSarah HermannKathrin MutzeChiharu OtaMichael LindnerJürgen BehrAnne HilgendorffDarcy E WagnerMelanie KönigshoffPublished in: Respiratory research (2018)
Pirfenidone and Nintedanib exhibit distinct effects on murine and human epithelial cells, which might contribute to their anti-fibrotic action. Human 3D-LTCs represent a valuable tool to assess anti-fibrotic mechanisms of potential drugs for the treatment of IPF patients.
Keyphrases
- idiopathic pulmonary fibrosis
- pulmonary fibrosis
- endothelial cells
- interstitial lung disease
- end stage renal disease
- induced pluripotent stem cells
- chronic kidney disease
- ejection fraction
- pluripotent stem cells
- newly diagnosed
- peritoneal dialysis
- systemic sclerosis
- human health
- patient reported
- replacement therapy