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Citriperazines A-D produced by a marine algae-derived fungus Penicillium sp. KMM 4672.

Anton Nikolaevich YurchenkoDmitry V BerdyshevOlga F SmetaninaElena V GirichOlesya I ZhuravlevaAnton B RasinYuliya V KhudyakovaRoman S PopovSergey A DyshlovoyGunhild von AmsbergShamil Sh Afiyatullov
Published in: Natural product research (2019)
Four new diketopiperazine alkaloids, citriperazines A-D were isolated from algae-derived Penicillium sp. KMM 4672. The structures of compounds 1-4 were determined using spectroscopic methods. The absolute configurations of compounds 1 and 4 were established by comparison of calculated and experimental ECD spectra. The cytotoxicity of compounds 1-4 against several human prostate cell lines was evaluated.
Keyphrases
  • prostate cancer
  • endothelial cells
  • molecular docking
  • benign prostatic hyperplasia
  • pluripotent stem cells