USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.

Zhe DongShuai GuoYue WangJun ZhangHaojie LuoGuoliang ZhengDong YangTao ZhangLiucun YanLi SongKejia LiuZhe SunXiang-Yu MengZhichao ZhengJianjun ZhangYan Zhao

Published in: OncoTargets and therapy (2020)

Our study suggests that USP19 promoted tumor progression by inducing MMP2/MMP9 expression and related enzyme activity. Hence, USP19 may be a valuable prognostic predictor for GC, and the USP19-MMP2/MMP9 axis could serve as a therapeutic target.

Keyphrases

cell migration
poor prognosis
mass spectrometry
binding protein
drug induced
simultaneous determination
liquid chromatography