Frequency of submicroscopic chromosomal aberrations in pregnancies without increased risk for structural chromosomal aberrations: systematic review and meta-analysis.

Malgorzata Ilona SrebniakM JoostenM F C M KnapenL R ArendsM PolakS van VeenA T J I GoD Van Opstal

Published in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2018)

This systematic review shows that a significant proportion of fetuses in a general pregnant population carry a submicroscopic pathogenic CNV. Based on these figures, all women should be informed on their individual risk for all pathogenic chromosomal aberrations and not only for common trisomies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

Keyphrases

copy number
systematic review
meta analyses
genome wide
gestational age
dna methylation
pregnancy outcomes
polycystic ovary syndrome
pregnant women
preterm birth
type diabetes
gene expression
breast cancer risk
randomized controlled trial
insulin resistance