A ratiometric triazine-based colorimetric and fluorometric sensor for the recognition of Zn2+ ions and its application in human lung cancer cells.
Sukhendu MandalDibyendu SainMd Majharul IslamDipanjan BanikMuthaimanoj PeriyasamySukhendu MandalAjit Kumar MahapatraArik KarPublished in: Analytical methods : advancing methods and applications (2021)
Herein, we introduce new ratiometric 2,4,6-triamino-1,3,5-triazine-based probes (R1 and R2) having three different binding sites for three metal ion binders, which can selectively detect Zn2+ ions and, particularly, the probe R1 strongly interacts with the human lung cancer cell line (A549). Both the probes R1 and R2 are competently selective towards the Zn2+ ions with the detection limits of 1.22 × 10-7 M and 1.13 × 10-7 M, respectively. The changes in the structure and absorption properties of the probes are explained by density functional theory (DFT) and time dependent density functional theory (TDDFT) calculations. The absorption and fluorescence color change in the solid TLC plate makes it a brilliant Zn2+ sensor in a portable form.
Keyphrases
- density functional theory
- living cells
- fluorescent probe
- quantum dots
- molecular dynamics
- single molecule
- endothelial cells
- heavy metals
- sensitive detection
- small molecule
- hydrogen peroxide
- energy transfer
- induced pluripotent stem cells
- fluorescence imaging
- pluripotent stem cells
- gold nanoparticles
- photodynamic therapy
- water soluble
- real time pcr
- loop mediated isothermal amplification