Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy.
Shivraj GrewalSriram GubbiAndin FosamCaroline SedmakShanaz SikderHarsha TalluruRebecca J BrownRanganath MuniyappaPublished in: Journal of the Endocrine Society (2019)
Leptin replacement therapy has significant effects on important metabolic pathways implicated in patients with lipodystrophy. Continued metabolomic studies may provide further insight into the mechanisms of action of leptin replacement therapy and provide novel biomarkers of lipodystrophy.Abbreviations: 1,5-AG, 1,5-anhydroglucitol; 11βHSD1, 11-β hydroxysteroid dehydrogenase 1; BCAA, branched-chain amino acid; FFA, free fatty acid; GC-MS, gas chromatography mass spectrometry; IDO, indoleamine 2,3-dioxygenase; IFN-γ, interferon-γ; m/z, mass to charge ratio; OGTT, oral glucose tolerance test; TDO, tryptophan 2,3-dioxygenase; TNF-α, tumor necrosis factor-α; UPLC-MS/MS, ultra-performance liquid chromatography-tandem mass spectrometry.
Keyphrases
- replacement therapy
- liquid chromatography tandem mass spectrometry
- gas chromatography mass spectrometry
- solid phase extraction
- simultaneous determination
- ms ms
- smoking cessation
- fatty acid
- rheumatoid arthritis
- high performance liquid chromatography
- amino acid
- dendritic cells
- tandem mass spectrometry
- gas chromatography
- high resolution
- immune response
- liquid chromatography
- quantum dots
- mass spectrometry
- highly efficient