Fecal Microbiome, Metabolites, and Stem Cell Transplant Outcomes: A Single-Center Pilot Study.
Jessica R Galloway-PeñaChristine B PetersonFarida MalikPranoti V SahasrabhojaneDimpy P ShahChelcy E BrumlowLily G CarlinRoy F ChemalyJin Seon ImGabriela RondonEdd FelixLucas VeillonPhilip L LorenziAmin M AlousiRobert R JenqDimitrios P KontoyiannisElizabeth J ShpallSamuel A ShelburnePablo C OkhuysenPublished in: Open forum infectious diseases (2019)
Longitudinal analysis of fecal microbiome and metabolites after HSCT identified butyrate and indole as potential surrogate markers for microbial diversity and specific taxa. Further studies are needed to ascertain whether fecal metabolites can be used as biomarkers of acute iGVHD or bacteremia after HSCT.
Keyphrases
- ms ms
- stem cells
- liver failure
- hematopoietic stem cell
- microbial community
- respiratory failure
- cross sectional
- drug induced
- intensive care unit
- risk assessment
- aortic dissection
- multidrug resistant
- mesenchymal stem cells
- skeletal muscle
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- cell therapy
- mechanical ventilation