A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions.

Tapas MakarVamshi K NimmagaddaPoornachander R GudaBrian HamptonWeiliang HuangMaureen A KanePaul S FishmanBernard PessacChristopher T BeverDavid Trisler

Published in: Stem cell research & therapy (2018)

These results suggest a practical method for obtaining large numbers of CD34+ cells from humans to allow studies on their potential to differentiate into other cell types.

Keyphrases

stem cells
single cell
cell therapy
endothelial cells
peripheral blood
bone marrow
induced pluripotent stem cells
genome wide
pluripotent stem cells
case control
bioinformatics analysis
mesenchymal stem cells
risk assessment
dna methylation