A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2).

Ying Z MazzuJoshua ArmeniaGoutam ChakrabortyYuki YoshikawaSi'Ana A CogginsSubhiksha NandakumarTravis A GerkeMark M PomerantzXintao QiuHuiyong ZhaoMohammad O AtiqNabeela KhanKazumasa KomuraGwo-Shu Mary LeeSamson W FineConnor BellEdward O'ConnorHenry W LongMatthew L FreedmanBaek KimPhilip W Kantoff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We propose that increased expression of RRM2 is a mechanism driving poor patient outcomes in prostate cancer and that its inhibition may be of significant therapeutic value.

Keyphrases

poor prognosis
prostate cancer
dna repair

long non coding rna
radical prostatectomy
dna damage

dna damage response
copy number
transcription factor

gene expression
oxidative stress
genome wide identification