The Role of a Selective P2Y6 Receptor Antagonist, MRS2578, on the Formation of Angiotensin II-Induced Abdominal Aortic Aneurysms.
Xiao DuShilan ZhangQunyan XiangJingyuan ChenFeng TianJin XuXin LiYuansheng TanLing LiuPublished in: BioMed research international (2020)
The present study demonstrated that administration of MRS2578 exacerbated the progression and rupture of experimental AAA through promoting proinflammatory response and MMP expression and activity, which indicated a crucial role of the P2Y6 receptor in AAA development. Clinical Relevance. Purinergic P2Y receptors have attracted much attention since the P2Y12 receptor antagonist had been successfully applied in clinical practice. Elucidating the underlying mechanisms of AAA and exploring potential therapeutic strategies are essential to prevent its progression and reduce the mortality rate.
Keyphrases
- angiotensin ii
- abdominal aortic
- clinical practice
- angiotensin converting enzyme
- vascular smooth muscle cells
- poor prognosis
- working memory
- cardiovascular events
- high glucose
- binding protein
- risk factors
- drug induced
- cardiovascular disease
- type diabetes
- cell migration
- long non coding rna
- oxidative stress
- climate change