BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria.
Klára GotvaldováJitka ŠpačkováJiří NovotnýKamila BaslarováPetr JežekLenka RossmeislováJan GojdaKatarína SmolkováPublished in: Cancer & metabolism (2024)
Our data suggest that BCAA catabolism is required for the import of long chain carnitines (LC-CARs) into mitochondria, whereas the disruption of this link results in the redirection of activated FAs into TG synthesis and its deposition into LDs. We propose that this mechanism protects cells against mitochondrial overload with LC-CARs and it might be part of the universal reaction to amino acid perturbations during cancer growth, regulating FA handling and storage.
Keyphrases
- fatty acid
- amino acid
- cell death
- induced apoptosis
- cell cycle arrest
- simultaneous determination
- papillary thyroid
- oxidative stress
- reactive oxygen species
- endoplasmic reticulum
- electronic health record
- squamous cell
- mass spectrometry
- liquid chromatography
- big data
- endoplasmic reticulum stress
- squamous cell carcinoma
- solid phase extraction
- childhood cancer
- high resolution
- signaling pathway
- machine learning
- artificial intelligence
- lymph node metastasis
- pi k akt