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BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria.

Klára GotvaldováJitka ŠpačkováJiří NovotnýKamila BaslarováPetr JežekLenka RossmeislováJan GojdaKatarína Smolková
Published in: Cancer & metabolism (2024)
Our data suggest that BCAA catabolism is required for the import of long chain carnitines (LC-CARs) into mitochondria, whereas the disruption of this link results in the redirection of activated FAs into TG synthesis and its deposition into LDs. We propose that this mechanism protects cells against mitochondrial overload with LC-CARs and it might be part of the universal reaction to amino acid perturbations during cancer growth, regulating FA handling and storage.
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