RNautophagic regulation of DNMT3a-dependent DNA methylation by Linc00942 enhances chemoresistance in gastric cancer.

Liyuan Zhu Yiran ZhuFang LiYuan MengHanying WangWenxia XuJingfeng LuoXian WangLifeng FengHongchuan Jin

Published in: Clinical and translational medicine (2023)

Inhibition of autophagy increases Linc00942 expression to promote chemoresistance and autophagy activation or hypomethylating agent decitabine restores chemosensitivity by reducing global DNA methylation. Overall, this study identifies a novel methylation cascade linking impaired RNautophagy to global hypermethylation in chemoresistance, and provides a rationale for repurposing decitabine to overcome chemoresistance in cancer treatment.

Keyphrases

dna methylation
genome wide
long non coding rna
gene expression
acute myeloid leukemia
cell death
cell proliferation
poor prognosis
endoplasmic reticulum stress
long noncoding rna
oxidative stress
cancer stem cells
copy number
clinical trial
drug discovery