A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest.
Gavin D PerkinsChen JiCharles D DeakinTom QuinnJerry P NolanCharlotte ScomparinScott ReganJohn LongAnne SlowtherHelen PocockJohn J M BlackFionna MooreRachael T FothergillNigel ReesLyndsey O'SheaMark DochertyImogen GunsonKyee HanKarl CharltonJudith FinnStavros PetrouNigel StallardSimon GatesRanjit Lallnull nullPublished in: The New England journal of medicine (2018)
In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group. (Funded by the U.K. National Institute for Health Research and others; Current Controlled Trials number, ISRCTN73485024 .).